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NSABP Clinical Trials Overview

Protocol B-09
A Protocol to Compare Combined Chemotherapy With and Without Tamoxifen in the Management of Patients With Surgically Curable Breast Cancer

Specific Aims
To determine (1) whether L-PAM + 5-FU + tamoxifen (PFT) with surgery is more effective than surgery with L-PAM + 5-FU (PF) and (2) whether tamoxifen in combination with L-PAM + 5-FU (PFT) is more effective in patients whose tumors had positive estrogen-receptor sites.