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NSABP Clinical Trials Overview

Protocol B-13
A Protocol To Assess Sequential Methotrexate → Fluorouracil In Patients With Primary Breast Cancer And Negative Axillary Nodes Whose Tumors Are Negative For Estrogen Receptors

Specific Aims
The primary objective of this study is to determine whether the sequential combination M→F is more effective than no treatment with respect to disease-free survival and survival in patients whose tumors are estrogen-receptor-negative.

In addition, this study, in conjunction with Protocol B-14, will permit evaluation of treatment failure and survival in untreated patients relative to their ER level.