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NSABP Clinical Trials Overview

Protocol B-18
A "Unified" Trial to Compare Short, Intensive Preoperative Systemic Adriamycin-Cyclophosphamide Therapy with Similar Therapy Administered in Conventional Postoperative Fashion

Specific Aims
To determine whether four courses of preoperative chemotherapy will more effectively prolong disease-free survival and survival than do four courses of the same chemotherapy (Adriamycin and cyclophosphamide) given postoperatively.