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NSABP Clinical Trials Overview

Protocol B-19
A Clinical Trial to Compare Sequential Methotrexate, 5-Fluorouracil (M→F) with Conventional CMF in Primary Breast Cancer Patients with Negative Nodes and Estrogen-Receptor-Negative Tumors

Specific Aims
The objective of this study is to determine whether six cycles of conventional cyclophosphamide, methotrexate and 5-fluorouracil (CMF) are as effective with respect to disease-free survival and survival as six cycles of sequential methotrexate and 5-fluorouracil (M→F) followed by leucovorin for negative-node patients whose tumors are estrogen-receptor-negative.