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NSABP Clinical Trials Overview

Protocol C-01
A Clinical Trial to Evaluate Postoperative Immunotherapy and Postoperative Systemic Chemotherapy in the Management of Resectable Colon Cancer

Specific Aims
To determine if the disease-free survival and survival of patients who have had a "curative" resection of the colon is improved by the addition of (1) the three-drug regimen, 5-FU, MeCCNU and vincristine, or (2) postoperative BCG immunotherapy. This study was also designed to provide information relative to the pathology of colon cancer that will contribute to a greater understanding of the natural history of this cancer so that subsets of patients who are at higher risk of recurrence can be identified.